The great-nephew of the 1st Duke of Alcalá, he was born in Seville on 10 May 1583 into a family environment imbued with an awareness of literature. Although his father died when he was seven, he received a thorough education and soon showed a huge fondness for the humanities--which led him to surrounded himself with the city's best humanists at his Sevillian mansion--and above all for painting, of which he amassed an outstanding collection, prominent among which is the oeuvre of José de Ribera, whom he met when serving as viceroy of Naples.